Tech Focus: Prognosticating the Future of the Bioreactor
Specific Demands Will Impact the Ongoing Evolution of this Device
Genetic Engineering News, Jan 15 2008; Vol. 28, No. 2
[GEN_ENG_NEWS_Jan15_2008_VSingh.pdf]

2008

Disposable Technology

Upstream processes in antibody production: Evaluation of critical parameters
Biotechnol Adv Vol 1, 46-72
[BiotechnolAdv_Vol26_2008_Upstream.pdf]

2008

Monoclonal Antibodies

Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales
J Virological Methods, Vol 145(2); 155-161
[JVirolMethods_Vol145_2007_Adenovirus.pdf]

2007

Adenovirus

Whatever happened to ·.Smallpox?
Discover Magazine
[Discover2007_Smallpox.pdf]

2007

Disposable Technology

Considerations & Applied Solutions for Cell Therapy Product Development and Commercialization
Progenitor Cell Therapy LLC; presented at symposium [Progenitor_CellTherapy.pdf]

2007

Cell Therapy

Personalized Cell-Based Medicine: Activated and Expanded T Cells for Adoptive Immunotherapy
BioProcessing Journal, Vol 6, No. 2
[Levine_BPI2007_TCells.pdf]

2007

Cell Therapy

Establishment of a Waveú bioreactor scale-down model for process development and characterization studies
Bristol-Myers Squibb. ACS 2007 presentation
[KhattakACS2007.pdf]

2007

Mammalian Cell Culture

Single-Use Technologies - A contract biomanufacturer's perspective
BioPharm International, Suppl, Nov 2007
[SingleUse_Tech_CMO_BioPharm2007.pdf]

2007

Disposable Technology

Wave Disposable Bioreactors - a pioneering technology
BioPharm International, vol 20, no. 10
[BioPharmIntl_Vol_20_No_10_Oct2007.pdf]

2007

Disposable Technology

CMOs Focused on Meeting Needs and Time Lines
Genetic Engineering News, Oct 1, 2007; vol 27, no. 17
[GEN_ENG_NEWS_Oct1_2007_CMO_BioInvent_PacificGMP.pdf]

2007

Disposable Technology

Disposables crucial in future of patient-specific meds
Pharma Technologist.com
[Disposables_FuturePatient_2007.pdf]

2007

Disposable Technology

Making Waves in Cell Therapy: The WAVE Bioreactor for the Generation of Adherent and Non-adherent Cells for Clinical Use
Univ of Pennsylvania Abramson Cancer Inst.
[ISCT_2007_WAVE_Levine_Final.pdf]

2007

Microcarriers

Disposables crucial in future of patient-specific meds
in-Pharma Technologist.com
[Disposables_FuturePatient_2007.pdf]

2007

Disposable Technology

Evaluation of a novel Wave Bioreactor(R) cellbag for aerobic yeast cultivation.
Bioprocess Biosyst Eng. 2007 Mar 6
[Merck_Mikola_Bioprocess_Biosyst_Eng_2007.pdf]

2007

Microbial

Plasmid DNA Production in the Wave Bioreactor Under cGMP Conditions
ASGT Annual Meeting - Seattle
[pDNA_Poster_COH2007.pdf]

2007

Cell Therapy

Perfusion Culture of Hybridoma Cells for Hyperproduction of IgG(2a) Monoclonal Antibody in a Wave Bioreactor-Perfusion Culture System
Biotechnology Prog, 23(1):255-264
[MIT_Tang_etal_Biotechnol_Prog_2007.pdf]

2007

Monoclonal Antibodies

Cholesterol Delivery to NS0 Cells: challenges and solutions in disposable linear low-density polyethylene-based bioreactors
J Bioscience & Bioengineering, Vol 103, No. 1, pgs 50-59
[Okonkowski_etal_J_BioSci_BioEng_2007.pdf]

2007

Monoclonal Antibodies

Lentiviral Vector Assists Gene Therapy
GEN ENG NEWS, June 1, 2007 [Lentiviral_GEN_ENG_NEWS_June2007.pdf]

2007

Cell Therapy

Demand Strong for Upstream Systems
GEN ENG NEWS Vol 27, No 14
[GEN_ENG_NEWS_Aug2007.pdf]

2007

Disposable Technology

Establishment of a mink enteritis vaccine production process in stirred-tank reactor and WAVE Bioreactor microcarrier culture in 1-10 L scale
Vaccine, Vol 25, Issue 20
[Vaccine_Vol25_2007_Microcarrier_Abstract.pdf]

2007

Vaccine

Production of selenomethionyl-derivatized proteins in baculovirus-infected insect cells
Protein Science, Vol 16:2023-2029
[ProteinSci_Vol16_2007_InsectCells.pdf]

2007

Baculovirus

Wave microcarrier cultivation of MDCK cells for influenza virus production in serum containing and serum-free media
Vaccine, Vol 24, Issues 35-36
[Vaccine_Vol24_2006_Microcarrier.pdf]

2006

Vaccine

Using the Allergic Immune System to Target Breast Cancer: Production of Anti-MUC1 IgE Monoclonal Antibodies
Presented at San Antonio Breast Cancer Symposium (December 14-17, 2006)
[Stanford_U_Mollick.pdf]

2006

Monoclonal Antibodies

Process Considerations for Cell-Based Influenza Vaccines
Pharmaceutical Technology
[PharmTech-PharmManuf_Process_2006.pdf]

2006

Vaccines

Serum-Free Suspension Large-Scale Transient Transfection of CHO Cells in WAVE Bioreactors
Molecular Biotechnology, Vol 34, Issue 2, pgs 191-200
[Serum_Free_Suspension_Large Oct2006.pdf]

2006

Mammalian Cell Culture

Evolution of a Gene Therapy Company
Introgen Therapeutics - presented at EU Antibodies & Recombinant - Barcelona, Spain
[Introgen_WilBio_Barcelona 2006.pdf]

2006

Cell Therapy

"They Said it Wouldn't Work"
India Today International
[IndiaToday_Feb2006.pdf]

2006

Disposable Technology

Assessing a disposable bioreactor for attachment-dependent cell cultures
Biopharm
[Schering_Plough_BioPharm_Namdev_2_2000.pdf]

2006

Microcarriers

Case Study of a Clinical-Scale CGMP Production Facility
BioProcess International, Vol 4, No. 6 2006
[BioProcess_Cytovance_June2006.pdf]

2006

Disposable Technology

Bioprocessing Systems Go Disposable
Chemical Engineering Progress, May 2006, Vol 102, No. 5
[BioprocessingSystems_May2006.pdf]

2006

Disposable Technology

The Use of Disposable Technologies in Antibody Manufacturing Processes
Genentech
[IBCDisposables_2005.pdf]

2005

Monoclonal Antibodies

Evaluation of Disposable Bioreactors: Rapid Production of Recombinant Proteins By Several Animal Cell Lines - Oct â05
Bioprocess International Industry Yearbook, Vol 3, No. 9, October, 2005, pages 36-44. [BioprocInt_Oct2005.pdf]

2005

Mammalian Cell Culture

Steel vs Bag: Comparison of Process Performance and Production Quality
Amgen
[IBC_BPI_Conf_Sept_2005_Amgen.pdf]

2005

Disposable Technology

Growing cholesterol-dependent NS0 myeloma cell line in the Wave Bioreactor system: Overcoming cholesterol-polymer interaction by using pretreated polymer or inert fluorinated ethylene propylene.
Presented at 2004 ACS. Printed Biotechnol Prog. 2005 Jul-Aug; 21 (4): 1341-6 [Kadaruman_Biotechnol_Prog_2005.pdf]

2005

Baculovirus

Disposable Bioreactors Become Standard Fare
GEN ENG NEWS Vol 25, No 14
[GEN_ENG_Aug2005_Disposables_Glaser.pdf]

2005

Disposable Technology

Adenovirus Production and Recovery using a Wave Bioreactor
SAIC- Frederick, NCI
[ACS2004_SAIC_Ekstrom.pdf]

2004

Adenovirus

Development of a Large-Scale Cell Bank in Cryobags for the Production of Biologics
Merck Research - presented at CCE IX
[Merck_Cancun_2004.pdf]

2004

Disposable Technology

GMP Production and Testing of Xcellerated T Cells for the Treatment of Patients with CLL
Cytotherapy, Vol 6, No 6, pgs 554-562
[Cytotherapy2004_Xcyte.pdf]

2004

Cell Therapy

Scalability of a Disposable Bioreactor from 25L - 500L Run in Perfusion Mode with a CHO-based Cell Line
Bioprocessing Journal, Vol 3, No 4
[Arizeke_BioProcessing_JulyAug2004.pdf]

2004

Protein Production

Semi-automated process for the factory-like production of recombinant proteins in the baculovirus system.
Novartis - presented at Recombinant Protein Production meeting
[Poster_Tavira_2004.pdf]

2004

Protein Production

The Happy Marriage of PEI and Wave in Large-scale transient transfection
Novartis Institute
[Novartis_CancunHEK2004.pdf]

2004

Transient Transfection

Validation of Bioreactors: Disposable vs. Reusable
BioProcess International Industry Yearbook
[BioProcessIntl_VV_Aug2004.pdf]

2004

Disposable Technology

Comparison of a Static Process and a Bioreactor-based Process for the GMP Manufacture of Autologous Xcellerated T Cells for Clinical Trials
Bioprocessing Journal, Vol 2, No 6 2003
[Xcyte2003.pdf]

2003

Cell Therapy

Production of Adenoviral Vectors for Gene Therapy in Suspension Serum Free Cultures
Presentation at Viral Vectors
[viralvectors03intgen.pdf]

2003

Adenovirus

On-line Purification of Monoclonal Antibodies Using an Integrated Stirred-Tank Reactor/Expanded-Bed Adsorption System
Biotechnol. Progress, Vol 18
[mit_online_purification.pdf]

2002

Monoclonal Antibodies

Optimisation of Protein Expression and Establishment of the Wave Bioreactor for Baculovirus/Insect cell Culture
Cytotechnology, Vol 38, pgs 77-85
[Cytotechnology_2002_issue_38_Wave_Optimization.pdf]

2002

Protein Production

Characterisation and Operation of a Disposable Bioreactor as a Replacement for Conventional Steam In Place Inoculum Bioreactors for Mammalian Cell Culture Processes
Lonza Biologics - presented at ACS
[acs_poster2002lonza.pdf]

2002

Mammalian Cell Culture

Evaluation of DO and pH as key parameters for cell metabolic shift in the Wave reactor
MIT - presented at ACS
[acs_poster2002mit.pdf]

2002

Monoclonal Antibodies

From Puddles to Waves: Journey to Consistency of Large Scale Expression
Chiron
[baculov02chiron.pdf]

2002

Protein Production

Perfusion Culture in Disposable Bioreactors
Genetic Engineering News, Vol 21, No. 7
[GEN_ENG_NEWS_2001_Perfusion.pdf]

2001

Monoclonal Antibodies

Disposable Bioreactor for Cell Culture Using Wave-Induced Agitation
Cytotechnology, Vol 30, pgs 149-158
[CYTO30_1999SinghV.pdf]

1999

Monoclonal Antibodies

Purification of Recombinant HIS-Tagged Viral proteins and evaluation of their sensitivity and specificity for detecting viral antibodies in Rodent Sera by ELISA - Feb â01
K. Dhawan Baculovirus Conference, 2001. [baculo_2001.pdf]

2001

Baculovirus