Advantages

• High cell density and productivity (>87x106 cells/ml max reported)
• No pumparound loop design minimizes shear damage and contamination
• Cell retention 99% for >10 micron
• Presterile, ready to use, low cost
• Patents pending

Perfusion Application: CHO cell for MAB production

• Scale up was done from 1 to 100L in Wave Bioreactor
• System1000 was inoculated with 100L and brought up to 500L volume
• Continuous perfusion was started at 3x106 cell/ml at 1 volume per day
• Total perfusion was 15,000L perfused over 30 day period
• Cell density maintained over run was > 20x106 cells/ml
• Entire process ö Completely Disposable!