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Learning Center - Case Studies Protocols Case Studies

GMP Inoculum Propagation: Application 1


Process Development
  • Batch cultivation of CHO cells in 5L bioreactor, 20L Wave, and 100L bioreactor
  • Comparable cell density and viability observed
  • Monoclonal antibody profiles comparable
  • Wave yield: 1.2 g/L at 100L scale ö equivalent to STR
 
 
5L     10L 100L     1000L

GMP Inoculum Propagation: Application 2

Manufacturing



  • Wave 20P bioreactor platform technology for seed train inoculums using Fed Batch in development
  • 1L>10L Seed up to 10,000L traditional bioreactors
  • Replaces all the 1-10 Spinners for the seed train
  • Saved $$$$ on cleaning and preparation
  • Currently developing a seed train inoculum with the Wave System200 for the Manufacturing Suite
  • 100L Seed a 1600L Traditional bioreactor
 
 
 
20L   200L    1600L