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Wave Biotech was founded by Dr. Vijay Singh, a recognized authority on large-scale cell culture and fluid mixing. Dr. Singh is the author of many technical papers and the holder of several US patents. He has been involved with the design and operation of bioreactors since 1980. The concept of wave-induced agitation for fluid mixing and oxygenation in inflated plastic bags was pioneered by him in 1995 as a replacement for expensive and labor-intensive stirred tank bioreactors. This concept was developed into what is now known as the Wave Bioreactor, hundreds of which have been sold since their introduction in 1998. Technical innovations included the development of bags with internal filters (patents pending) for perfusion and the scale up to culture volumes over 500 liters. Spinoffs of the technology include Wave Mixers which provide non-invasive sterile mixing, Wave Warmers for thawing applications, and a host of instrumentation suitable for introduction into bags. |
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